Chloride channels - Potassium channels - Calcium channels - Sodium channels - TRPC

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By kind permission of WikiGenes

• Chloride channels:

CLCA1, CLCA2, CLCA3, CLCA4

CLCN1, CLCN2, CLCN3, CLCN4, CLCN5, CLCN6, CLCN7, CLCNKA, CLCNKB

CLIC1, CLIC2 , CLIC3, CLIC4 , CLIC5 , CLIC6

CLNS1A, CLNS1B

• Potassium channels:

--Voltage-gated potassium channels

-------Delayed rectifier / non-inactivating

• Kvα1.x - Shaker-related: Kv1.1 (KCNA1), Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.4 (KCNA4), Kv1.5 (KCNA5), Kv1.6 (KCNA6), Kv1.7 (KCNA7), Kv1.8 (KCNA10)
• Kvα2.x - Shab-related: Kv2.1 (KCNB1), Kv2.2 (KCNB2)
• Kvα3.x - Shaw-related: Kv3.1 (KCNC1), Kv3.2 (KCNC2)
• Kvα7.x: Kv7.1 (KCNQ1) - KvLQT1, Kv7.2 (KCNQ2), Kv7.3 (KCNQ3), Kv7.4 (KCNQ4), Kv7.5 (KCNQ5)
• Kvα10.x: Kv10.1 (KCNH1)

-------A-type potassium channel / rapidly inactivating

• Kvα3.x - Shaw-related: Kv3.3 (KCNC3), Kv3.4 (KCNC4)
• Kvα4.x - Shal-related: Kv4.1 (KCND1), Kv4.2 (KCND2), Kv4.3 (KCND3)

-------Outward-rectifying

• Kvα10.x: Kv10.2 (KCNH2)

-------Inward-rectifying

• Kvα11.x - ether-a-go-go potassium channels - hERG: Kv11.1 (KCNH2) , Kv11.2 (KCNH6), Kv11.3 (KCNH7)

-------Slowly activating

• Kvα12.x: Kv12.1 (KCNH8), Kv12.2 (KCNH3), Kv12.3 (KCNH4)

-------Modifier/silencer

• Kvα5.x: Kv5.1 (KCNF1)
• Kvα6.x: Kv6.1 (KCNG1), Kv6.2 (KCNG2), Kv6.3 (KCNG3), Kv6.4 (KCNG4)
• Kvα8.x: Kv8.1 (KCNV1), Kv8.2 (KCNV2)
• Kvα9.x: Kv9.1 (KCNS1), Kv9.2 (KCNS2), Kv9.3 (KCNS3)

• Kvβ1 (KCNAB1) Kvβ2 (KCNAB2) Kvβ3 (KCNAB3)
• minK (KCNE1) MiRP1 (KCNE2) MiRP2 (KCNE3) MiRP3 (KCNE4)
• KCNE1-like (KCNE1L)
• KCNIP1 (KCNIP1) KCNIP2 (KCNIP2) KCNIP3 (KCNIP3) KCNIP4 (KCNIP4)

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--Calcium-activated potassium channels

----BK channel

• Kca1.x : Kca1.1 (KCNMA1)

----SK channel

• Kca2.x : Kca2.1 (KCNN1), Kca2.2 (KCNN2), Kca2.3 (KCNN3)
• Kca3.x: Kca3.1 (KCNN4)
• Kca4.x: Kca4.1 (KCNT1), Kca4.2 (KCNT2)

----IK channel

• Kca5.x: Kca5.1 (KCNU1)

--Inward-rectifier potassium channels

• Kir (1.1, 2.1, 2.2, 2.3, 2.4) • GIRK/Kir (3.1, 3.2, 3.3, 3.4) • Kir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1)

--Two-pore-domain potassium channels

• KCNK1, KCNK2, KCNK3, KCNK4, KCNK5, KCNK6
• KCNK7, KCNK9, KCNK10, KCNK12,
• KCNK13, KCNK15, KCNK16, KCNK17, KCNK18

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• Sodium channels:

----ALPHA subunits

• Navα1.1 (SCN1A), Navα1.2 (SCN2A), Navα1.3 (SCN3A), Navα1.4 (SCN4A), Navα1.5 (SCN5A),
• Navα1.6 (SCN8A), Navα1.7 ( SCN9A), Navα1.8 (SCN10A), Navα1.9 (SCN11A), SCN7A

----BETA subunits

• Navβ1 (SCN1B), Navβ2 (SCN2B), Navβ3 (SCN3B), Navβ4 (SCN4B)

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• Calcium channels

--Voltage-gated

----L-type: Cav1.1 (CACNA1S), Cav1.2(CACNA1C), Cav1.3 (CACNA1D), Cav1.4 (CACNA1F)

----P-type/Q-type: Cav2.1 (CACNA1A)

----N-type: Cav2.2 (CACNA1B)

----R-type: Cav2.3 (CACNA1E)

----T-type: Cav3.1 (CACNA1G) Cav3.2 (CACNA1H) Cav3.3 (CACNA1I)

----α2δ subunits

• CACNA2D1 , CACNA2D2

----β subunits

• CACNB1, CACNB2, CACNB3, CACNB4

----γ subunits

• CACNG1, CACNG2, CACNG3, CACNG4

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--Ligand-gated potassium channels

----IP3 receptor

----Ryanodine receptor

----Two-pore channel

----Cation channels of sperm - CatSper

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• Proton channels

• Transient receptor potential channels

• TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, TRPC7

• TRPV1, TRPV2, TRPV3, TRPV4, TRPV5, TRPV6

• TRPA1

• TRPM1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8

• TRPP1, PKDREJ, PKD1L1, PKD1L2, PKD1L3

• TRPP2, TRPP3, TRPP5

• TRPML1 TRPML2 TRPML3

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